Our approach

To therapeutically differentiate the two types of eating, and to treat eating disorders and obesity-related diseases by reducing hedonic eating

Eating to live
Homeostatic Eating
Controls energy balance by increasing the desire to eat following the depletion of energy

Hedonic Eating

Living to eat
Hedonic Eating
Can override homeostatic eating, increasing the desire to eat highly palatable foods during periods of energy abundance

On average, sedentary Americans eat 80% more calories per day than the USDA recommends.

Highly palatable foods are readily available in the US, which is a driver for increasing obesity rates. Reducing caloric intake by as little as 10% could have a meaningful impact on weight loss, and lead to reductions in obesity-related morbidities.

Binge Eating in the US

3b
0
%
of adults experience binge eating
scale OB
0
%
of individuals with BED are obese
Rx
Only
0
%
with disorder receive treatment

Binge eating disorder was added as a diagnosable eating disorder to DSM-5 in 2013

Binge eating disorder is characterized by recurrent binge eating episodes during which a person feels a loss of control over his or her eating

Obesity in the US

scale OB
0
%
of adults are obese
Scale MO
0
%
of adults are morbidly obese
obchild
0
%
of children are obese

Obesity-related healthcare costs are $190B per year, or nearly 21% of all healthcare spending

Obesity is defined as a Body Mass Index (BMI) >30 kg/m2 and morbid obesity is defined as a Body Mass Index (BMI) >40 kg/m2

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A recent Gallup Poll shows that even though more Americans than ever are heavier than 200 pounds (28% today vs 24% ten years ago), fewer are willing to lose weight (54% today vs 58% ten years ago).

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Why are 2 out of 3 Americans overweight, obese, or morbidly obese?

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    Since the early 1960s the average daily caloric intake of Americans has increased by ~500 calories per day
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    The amount of physical activity during the workday has decreased: in 1960 1 in 2 people had a job that was physically active. Today that number is only 1 in 5
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    Only 24% of Americans are meeting guidelines for aerobic physical activity and muscle-strengthening activity

These factors alone do not explain the increase in obesity in the US, however evidence has emerged that a change in the American diet towards more ultra-processed/highly palatable foods could be a significant driver: foods with high glycemic index and glycemic load may be displacing low-energy nutrient dense unprocessed and minimally processed foods. Ultra-processed foods are also less satiating since human satiety mechanisms are more sensitive to volume than energy content.

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Prevalence of Self-Reported Obesity Among U.S. Adults by State and Territory

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How can we impact obesity in the US?

Our therapeutic rationale is to help people avoid highly palatable food and make healthier eating choices.

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Obesity and Cancer Association

Excess body weight accounts for ~3.9% of all cancers globally, ranging from less than 1% in low-income countries to 7% or 8% in some high-income countries

Cancer incidence appears to be rising disproportionately in younger US adults, and in consecutively younger birth cohorts for half of the obesity-related cancers

E.g. each 5‐unit increase in BMI is associated with 50% increased risk of endometrial cancer and each 5‐unit increase in BMI is associated with a 48% increased risk of esophageal adenocarcinoma
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